@article{78356c2fd55a48f8b1510ad1573ca107,
title = "Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system",
abstract = "Plants and animals detect the presence of potential pathogens through the perception of conserved microbial patterns by cell surface receptors. Certain solanaceous plants, including tomato, potato and pepper, detect flgII-28, a region of bacterial flagellin that is distinct from that perceived by the well-characterized FLAGELLIN-SENSING 2 receptor. Here we identify and characterize the receptor responsible for this recognition in tomato, called FLAGELLIN-SENSING 3. This receptor binds flgII-28 and enhances immune responses leading to a reduction in bacterial colonization of leaf tissues. Further characterization of FLS3 and its signalling pathway could provide new insights into the plant immune system and transfer of the receptor to other crop plants offers the potential of enhancing resistance to bacterial pathogens that have evolved to evade FLS2-mediated immunity.",
author = "Hind, {Sarah R.} and Strickler, {Susan R.} and Boyle, {Patrick C.} and Dunham, {Diane M.} and Zhilong Bao and O'Doherty, {Inish M.} and Baccile, {Joshua A.} and Hoki, {Jason S.} and Viox, {Elise G.} and Clarke, {Christopher R.} and Vinatzer, {Boris A.} and Schroeder, {Frank C.} and Martin, {Gregory B.}",
note = "Funding Information: This research was supported by grants from the National Science Foundation to G.B.M. (IOS-1025642) and B.A.V. (IOS-1354215), the USDA-National Initiative in Food and Agriculture (2010-65108-20503) to G.B.M., the USDA Binational Agriculture Development Fund (IS-4931-16C) to G.B.M. and the National Institutes of Health (R01-GM078021) to G.B.M.; by the TRIAD foundation to G.B.M. and F.C.S.; by a Postdoctoral Fellowship from the Human Frontiers Science Program to P.C.B.; by a summer REU stipend to E.G.V. (National Science Foundation REU Site award DBI-1358843); and by internal funding from the Boyce Thompson Institute to S.R.S. Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",
year = "2016",
month = aug,
day = "22",
doi = "10.1038/nplants.2016.128",
language = "English (US)",
volume = "2",
journal = "Nature Plants",
issn = "2055-026X",
publisher = "Palgrave Macmillan",
number = "9",
}