TLR10 is a B cell intrinsic suppressor of adaptive immune responses

Nicholas J. Hess, Song Jiang, Xinyan Li, Yue Guan, Richard I. Tapping

Research output: Contribution to journalArticle

Abstract

Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the function of TLR10 remains unknown. We have found that Abmediated engagement of TLR10 on primary human B cells suppresses B cell proliferation, cytokine production, and signal transduction. When challenged with either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses. Adoptive transfer of splenic B cells into B cell-deficient mice revealed that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic. Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members and may provide a potential therapeutic target for diseases characterized by dysregulated B cell activity.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalJournal of Immunology
Volume198
Issue number2
DOIs
StatePublished - Jan 15 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Hess, N. J., Jiang, S., Li, X., Guan, Y., & Tapping, R. I. (2017). TLR10 is a B cell intrinsic suppressor of adaptive immune responses. Journal of Immunology, 198(2), 699-707. https://doi.org/10.4049/jimmunol.1601335