Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection

Martin Hunter, Vadim Backman, Gabriel Popescu, Maxim Kalashnikov, Charles W. Boone, Adam Wax, Venkatesh Gopal, Kamran Badizadegan, Gary D. Stoner, Michael S. Feld

Research output: Contribution to journalArticlepeer-review

Abstract

Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.

Original languageEnglish (US)
Article number138102
JournalPhysical review letters
Volume97
Issue number13
DOIs
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection'. Together they form a unique fingerprint.

Cite this