Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection

Martin Hunter; Vadim Backman; Gabriel Popescu; Maxim Kalashnikov; Charles W. Boone; Adam Wax; Venkatesh Gopal; Kamran Badizadegan; Gary D. Stoner; Michael S. Feld

doi:10.1103/PhysRevLett.97.138102

Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection

Martin Hunter, Vadim Backman, Gabriel Popescu, Maxim Kalashnikov, Charles W. Boone, Adam Wax, Venkatesh Gopal, Kamran Badizadegan, Gary D. Stoner, Michael S. Feld

Research output: Contribution to journal › Article › peer-review

Abstract

Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.

Original language	English (US)
Article number	138102
Journal	Physical review letters
Volume	97
Issue number	13
DOIs	https://doi.org/10.1103/PhysRevLett.97.138102
State	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

General Physics and Astronomy

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10.1103/PhysRevLett.97.138102

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title = "Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection",

abstract = "Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.",

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AU - Backman, Vadim

AU - Popescu, Gabriel

AU - Kalashnikov, Maxim

AU - Boone, Charles W.

AU - Wax, Adam

AU - Gopal, Venkatesh

AU - Badizadegan, Kamran

AU - Stoner, Gary D.

AU - Feld, Michael S.

PY - 2006

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AB - Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.

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Tissue self-affinity and polarized light scattering in the born approximation: A new model for precancer detection

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