Tissue factor: An enzyme cofactor and a true receptor

J. H. Morrissey

Research output: Contribution to journalArticlepeer-review


Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many - perhaps most - thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalThrombosis and Haemostasis
Issue number1
StatePublished - 2001


  • Factor VII
  • Factor VIIa
  • TFPI
  • Thrombotic risk factors
  • Tissue factor

ASJC Scopus subject areas

  • Hematology


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