Abstract
Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many - perhaps most - thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 66-74 |
| Number of pages | 9 |
| Journal | Thrombosis and Haemostasis |
| Volume | 86 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
Keywords
- Factor VII
- Factor VIIa
- TFPI
- Thrombotic risk factors
- Tissue factor
ASJC Scopus subject areas
- Hematology