Tissue Factor: A Key Molecule in Hemostatic and Nonhemostatic Systems

James H. Morrissey

Research output: Contribution to journalReview articlepeer-review


Tissue factor (also known as tissue thromboplastin or CD142) is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Because of its essential role in hemostasis, tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Recent research has also implicated tissue factor in a variety of nonhemostatic roles, including cell signaling, inflammation, vasculogenesis, and tumor growth and metastasis. This review focuses on both the well-known roles of tissue factor in hemostasis and thrombosis and the newer concepts of tissue-factor biology including how it functions as a signaling receptor and the possible role of blood-borne tissue factor in thrombosis.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalInternational Journal of Hematology
Issue number2
StatePublished - Feb 2004


  • CD142
  • Factor VII
  • Hemostasis
  • Thrombosis
  • Tissue factor

ASJC Scopus subject areas

  • Hematology


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