Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images

Masanori Takabayashi; Hassaan Majeed; Andre Kajdacsy-Balla; Gabriel Popescu

doi:10.1117/12.2538728

Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images

Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, Gabriel Popescu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The intrinsic markers of nanoscale morphological alteration in fixed tissue biopsy referred to as disorder strength and local correlation length, which can be easily and time-efficiently obtained from quantitative phase images, are introduced. After presenting how to extract these markers from quantitative phase images obtained by highly sensitive quantitative phase imaging system, spatial light interference microscopy (SLIM), we demonstrate the effectiveness of these markers for diagnosis of benign and malignant breast tissues.

Original language	English (US)
Title of host publication	Optical Design and Testing IX
Editors	Yongtian Wang, Pablo Benitez, Osamu Matoba
Publisher	SPIE
ISBN (Electronic)	9781510630871
DOIs	https://doi.org/10.1117/12.2538728
State	Published - 2019
Event	Optical Design and Testing IX 2019 - Hangzhou, China Duration: Oct 21 2019 → Oct 22 2019

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11185
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Optical Design and Testing IX 2019
Country	China
City	Hangzhou
Period	10/21/19 → 10/22/19

Keywords

Biopsy slide diagnosis
Breast cancer
Quantitative phase imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.2538728

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Cite this

Takabayashi, M., Majeed, H., Kajdacsy-Balla, A., & Popescu, G. (2019). Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images. In Y. Wang, P. Benitez, & O. Matoba (Eds.), Optical Design and Testing IX [111850B] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11185). SPIE. https://doi.org/10.1117/12.2538728

Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images. / Takabayashi, Masanori; Majeed, Hassaan; Kajdacsy-Balla, Andre; Popescu, Gabriel.

Optical Design and Testing IX. ed. / Yongtian Wang; Pablo Benitez; Osamu Matoba. SPIE, 2019. 111850B (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11185).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Takabayashi, M, Majeed, H, Kajdacsy-Balla, A & Popescu, G 2019, Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images. in Y Wang, P Benitez & O Matoba (eds), Optical Design and Testing IX., 111850B, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11185, SPIE, Optical Design and Testing IX 2019, Hangzhou, China, 10/21/19. https://doi.org/10.1117/12.2538728

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title = "Tissue diagnosis using nanoscale morphological markers extracted from quantitative phase images",

abstract = "The intrinsic markers of nanoscale morphological alteration in fixed tissue biopsy referred to as disorder strength and local correlation length, which can be easily and time-efficiently obtained from quantitative phase images, are introduced. After presenting how to extract these markers from quantitative phase images obtained by highly sensitive quantitative phase imaging system, spatial light interference microscopy (SLIM), we demonstrate the effectiveness of these markers for diagnosis of benign and malignant breast tissues.",

keywords = "Biopsy slide diagnosis, Breast cancer, Quantitative phase imaging",

author = "Masanori Takabayashi and Hassaan Majeed and Andre Kajdacsy-Balla and Gabriel Popescu",

note = "Funding Information: This work was supported by National Science Foundation (CBET-0939511 STC, DBI 1450962 EAGER, 1353368, and CBET-1040461 MRI) and by JSPS KAKENHI Grant No. 18K14150. Funding Information: This work was supported by National Science Foundation (CBET-0939511 STC, DBI 1450962 EAGER, IIP-1353368, and CBET-1040461 MRI) and by JSPS KAKENHI Grant No. 18K14150.; Optical Design and Testing IX 2019 ; Conference date: 21-10-2019 Through 22-10-2019",

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doi = "10.1117/12.2538728",

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series = "Proceedings of SPIE - The International Society for Optical Engineering",

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