THz-biology: Studying protein dynamics in solution

M. Havenith, U. Heugen, A. Bergner, S. Ebbinghaus, E. Bründermann, E. Larios, D. M. Leitner, M. Gruebele

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An approach to measure absorption spectra of solvated proteins was described using THz spectrometer. Mutants are designed to reveal chemically identified primary structures which significantly alter the secondary and tertiary structure. The amino acid isoleucine is replaced by the smaller alanine for the point mutation I61A. It was found that the solute changes the solvent structure in the layer around the lactose thereby affecting the collective intermolecular modes of the water in the TMz regime.

Original languageEnglish (US)
Title of host publicationConference Digest of the 2004 Joint 29th International Conference on Infrared and Millimeter Waves and 12th International Conference on Terahertz Electronics
EditorsM. Thumm, W. Wiesbeck
Pages731-732
Number of pages2
StatePublished - 2004
Externally publishedYes
EventConference Digest of the 2004 Joint 29th International Conference on Infrared and Millimeter Waves and 12th International Conference on Terahertz Electronics - Karlsruhe, Germany
Duration: Sep 27 2004Oct 1 2004

Publication series

NameConference Digest of the 2004 Joint 29th International Conference on Infrared and Millimeter Waves and 12th International Conference on Terahertz Electronics

Other

OtherConference Digest of the 2004 Joint 29th International Conference on Infrared and Millimeter Waves and 12th International Conference on Terahertz Electronics
Country/TerritoryGermany
CityKarlsruhe
Period9/27/0410/1/04

ASJC Scopus subject areas

  • General Engineering

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