Thyroid receptor subtypes: Structure and function in fish

Erik R. Nelson, Hamid R. Habibi

Research output: Contribution to journalArticle

Abstract

Thyroid hormones are important regulators of vertebrate growth and development, and are under the control of the hypothalamic-pituitary-thyroid axis. Nuclear thyroid receptors (TRs), which act as inducible transcription factors, mediate cellular functions of thyroid hormones. The molecular structure of several subtypes of TRs have been elucidated in vertebrate species, including N-terminal truncations as well as C-terminal variations in the domain responsible for binding hormone. In this paper, we review current information on the thyroid receptors studied in the vertebrate species with emphasis on recent findings in goldfish concerning functional significance of the thyroid receptor subtypes.

Original languageEnglish (US)
Pages (from-to)90-96
Number of pages7
JournalGeneral and Comparative Endocrinology
Volume161
Issue number1
DOIs
StatePublished - Mar 2009

Fingerprint

Thyroid Gland
Fishes
receptors
vertebrates
Vertebrates
thyroid hormones
fish
Thyroid Hormones
goldfish
Goldfish
chemical structure
Cytoplasmic and Nuclear Receptors
growth and development
Molecular Structure
Growth and Development
transcription factors
hormones
Transcription Factors
Hormones

Keywords

  • 11-ketotestosterone
  • Deiodinase
  • Estradiol
  • Estrogen
  • Gene expression
  • Goldfish
  • Gonad
  • Liver
  • Ovary
  • Regulation
  • Steroid
  • Testis
  • Testosterone
  • Thyroid receptor

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

Cite this

Thyroid receptor subtypes : Structure and function in fish. / Nelson, Erik R.; Habibi, Hamid R.

In: General and Comparative Endocrinology, Vol. 161, No. 1, 03.2009, p. 90-96.

Research output: Contribution to journalArticle

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