Thyroid hormone metabolism. A comparative evaluation

E. M. Kaptein, M. T. Hays, D. C. Ferguson

Research output: Contribution to journalReview articlepeer-review


Knowledge of thyroid hormone and iodide metabolism is derived from a combination of in vivo and in vitro studies in a variety of mammalian species including cats, dogs, and humans. Each species provides a unique opportunity to investigate various aspects of normal or altered thyroid hormone physiology. Availability of sensitive and specific human TSH assays has allowed detailed studies of the human hypothalamic-pituitary-thyroid axis which have not been possible in cats and dogs to date. Similarities and differences of thyroid hormone metabolism in dogs, cats, and humans provide the basis for a better understanding of normal physiology as well as shedding light on the significance of changes induced by spontaneous or induced thyroidal and nonthyroidal disorders.

Original languageEnglish (US)
Pages (from-to)431-466
Number of pages36
JournalVeterinary Clinics of North America - Small Animal Practice
Issue number3
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Small Animals


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