Thyroid hormone and reproduction: Regulation of estrogen receptors in goldfish gonads

Erik R. Nelson, Euan R.O. Allan, Flora Y. Pang, Hamid R. Habibi

Research output: Contribution to journalArticle

Abstract

There is increasing evidence that thyroid hormones influence reproduction in vertebrates. However, little information is available on the mechanisms by which this happens. As a first step in determining these mechanisms, we test the hypothesis that the estrogen receptor subtypes (ERα, ERβ-1, and ERβ-2) are regulated by the thyroid hormone, (T3), in the gonads of goldfish. All three subtypes were down-regulated by T3 in the testis or ovary. We also found evidence that T3 decreased pituitary gonadotropin expression and decreased transcript for gonadal aromatase. Collectively, it appears that T3 acts to diminish estrogen signaling by (1) decreasing pituitary LH expression and thus steroidogenesis, (2) down-regulating gonadal aromatase expression and thus decreasing estrogen synthesis from androgens, and (3) decreasing sensitivity to estrogen by down-regulating the ER subtypes. Goldfish are seasonal breeders, spawning once a year, and thus have two distinct periods of growth: somatic and reproductive. Circulating thyroid hormone levels have been found to increase just after spawning. Therefore, we propose that this may be an endocrine mechanism that goldfish use to switch their energy expenditure from reproductive to growth efforts in the goldfish. Mol. Reprod. Dev. 77: 784-794, 2010.

Original languageEnglish (US)
Pages (from-to)784-794
Number of pages11
JournalMolecular reproduction and development
Volume77
Issue number9
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Fingerprint

Goldfish
Gonads
Thyroid Hormones
Estrogen Receptors
Reproduction
Estrogens
Aromatase
Pituitary Gonadotropins
Triiodothyronine
Growth
Energy Metabolism
Androgens
Vertebrates
Testis
Ovary

Keywords

  • Androgen
  • Aromatase
  • Estrogen
  • FSH
  • Goldfish
  • LH
  • Nuclear receptor
  • Receptor
  • Thyroid hormone

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Thyroid hormone and reproduction : Regulation of estrogen receptors in goldfish gonads. / Nelson, Erik R.; Allan, Euan R.O.; Pang, Flora Y.; Habibi, Hamid R.

In: Molecular reproduction and development, Vol. 77, No. 9, 01.09.2010, p. 784-794.

Research output: Contribution to journalArticle

Nelson, Erik R. ; Allan, Euan R.O. ; Pang, Flora Y. ; Habibi, Hamid R. / Thyroid hormone and reproduction : Regulation of estrogen receptors in goldfish gonads. In: Molecular reproduction and development. 2010 ; Vol. 77, No. 9. pp. 784-794.
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