Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice: Design and phantom validation

S. A. Ermilov; R. Su; A. Conjusteau; F. Anis; V. Nadvoretskiy; M. A. Anastasio; A. A. Oraevsky

doi:10.1177/0161734615591163

Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice: Design and phantom validation

S. A. Ermilov
, R. Su
, A. Conjusteau
, F. Anis
, V. Nadvoretskiy
, M. A. Anastasio
, A. A. Oraevsky

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.

Original language	English (US)
Pages (from-to)	77-95
Number of pages	19
Journal	Ultrasonic Imaging
Volume	38
Issue number	1
DOIs	https://doi.org/10.1177/0161734615591163
State	Published - Jan 1 2016
Externally published	Yes

Keywords

mouse imaging
photoacoustic tomography
speed of sound tomography

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Online availability

10.1177/0161734615591163

Library availability

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title = "Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice: Design and phantom validation",

abstract = "In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.",

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note = "The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The work was supported by the Grant 5R01CA167446 from the National Cancer Institute (NIH). F. Anis was supported by the Department of Defense award W81XWH-13-1-0233.",

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doi = "10.1177/0161734615591163",

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AU - Ermilov, S. A.

AU - Su, R.

AU - Conjusteau, A.

AU - Anis, F.

AU - Nadvoretskiy, V.

AU - Anastasio, M. A.

AU - Oraevsky, A. A.

N1 - The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The work was supported by the Grant 5R01CA167446 from the National Cancer Institute (NIH). F. Anis was supported by the Department of Defense award W81XWH-13-1-0233.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.

AB - In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.

KW - mouse imaging

KW - photoacoustic tomography

KW - speed of sound tomography

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Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice: Design and phantom validation

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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