Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice: Design and phantom validation

S. A. Ermilov, R. Su, A. Conjusteau, F. Anis, V. Nadvoretskiy, M. A. Anastasio, A. A. Oraevsky

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.

Original languageEnglish (US)
Pages (from-to)77-95
Number of pages19
JournalUltrasonic Imaging
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • mouse imaging
  • photoacoustic tomography
  • speed of sound tomography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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