Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research

Sergey A. Ermilov; Richard Su; Andre Conjusteau; Tanmayi Oruganti; Kun Wang; Fatima Anis; Mark A. Anastasio; Alexander A. Oraevsky

doi:10.1117/12.2085028

Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research

Sergey A. Ermilov, Richard Su, Andre Conjusteau, Tanmayi Oruganti, Kun Wang, Fatima Anis, Mark A. Anastasio, Alexander A. Oraevsky

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2015
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781628414134
DOIs	https://doi.org/10.1117/12.2085028
State	Published - Jan 1 2015
Externally published	Yes
Event	Photons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States Duration: Feb 8 2015 → Feb 10 2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9323
ISSN (Print)	1605-7422

Other

Other	Photons Plus Ultrasound: Imaging and Sensing 2015
Country	United States
City	San Francisco
Period	2/8/15 → 2/10/15

Keywords

Mouse imaging
Optical absorption
Photoacoustic tomography
Speed of sound tomography
Wave inversion

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2085028

Fingerprint Dive into the research topics of 'Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research'. Together they form a unique fingerprint.

Cite this

Ermilov, S. A., Su, R., Conjusteau, A., Oruganti, T., Wang, K., Anis, F., Anastasio, M. A., & Oraevsky, A. A. (2015). Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2015 [93230N] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323). SPIE. https://doi.org/10.1117/12.2085028

Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research. / Ermilov, Sergey A.; Su, Richard; Conjusteau, Andre; Oruganti, Tanmayi; Wang, Kun; Anis, Fatima; Anastasio, Mark A.; Oraevsky, Alexander A.

Photons Plus Ultrasound: Imaging and Sensing 2015. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2015. 93230N (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ermilov, SA, Su, R, Conjusteau, A, Oruganti, T, Wang, K, Anis, F, Anastasio, MA & Oraevsky, AA 2015, Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2015., 93230N, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9323, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2015, San Francisco, United States, 2/8/15. https://doi.org/10.1117/12.2085028

Ermilov SA, Su R, Conjusteau A, Oruganti T, Wang K, Anis F et al. Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research. In Oraevsky AA, Wang LV, editors, Photons Plus Ultrasound: Imaging and Sensing 2015. SPIE. 2015. 93230N. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2085028

Ermilov, Sergey A. ; Su, Richard ; Conjusteau, Andre ; Oruganti, Tanmayi ; Wang, Kun ; Anis, Fatima ; Anastasio, Mark A. ; Oraevsky, Alexander A. / Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research. Photons Plus Ultrasound: Imaging and Sensing 2015. editor / Alexander A. Oraevsky ; Lihong V. Wang. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{9e41fbbf0a1347d5a989f3b24d7826ee,

title = "Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research",

abstract = "In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).",

keywords = "Mouse imaging, Optical absorption, Photoacoustic tomography, Speed of sound tomography, Wave inversion",

author = "Ermilov, {Sergey A.} and Richard Su and Andre Conjusteau and Tanmayi Oruganti and Kun Wang and Fatima Anis and Anastasio, {Mark A.} and Oraevsky, {Alexander A.}",

year = "2015",

month = jan,

day = "1",

doi = "10.1117/12.2085028",

language = "English (US)",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, {Alexander A.} and Wang, {Lihong V.}",

booktitle = "Photons Plus Ultrasound",

address = "United States",

note = "Photons Plus Ultrasound: Imaging and Sensing 2015 ; Conference date: 08-02-2015 Through 10-02-2015",

}

TY - GEN

T1 - Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research

AU - Ermilov, Sergey A.

AU - Su, Richard

AU - Conjusteau, Andre

AU - Oruganti, Tanmayi

AU - Wang, Kun

AU - Anis, Fatima

AU - Anastasio, Mark A.

AU - Oraevsky, Alexander A.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).

AB - In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).

KW - Mouse imaging

KW - Optical absorption

KW - Photoacoustic tomography

KW - Speed of sound tomography

KW - Wave inversion

UR - http://www.scopus.com/inward/record.url?scp=84928575861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928575861&partnerID=8YFLogxK

U2 - 10.1117/12.2085028

DO - 10.1117/12.2085028

M3 - Conference contribution

AN - SCOPUS:84928575861

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2015

Y2 - 8 February 2015 through 10 February 2015

ER -