Three-dimensional impedance map analysis of rabbit liver

Alexander D. Pawlicki; Alexander J. Dapore; Sandhya Sarwate; William D. O'Brien

doi:10.1121/1.3646024

Three-dimensional impedance map analysis of rabbit liver

Alexander D. Pawlicki, Alexander J. Dapore, Sandhya Sarwate, William D. O'Brien

Research output: Contribution to journal › Article › peer-review

Abstract

Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ± 1.3 and 7.0 ± 0.3 m for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.

Original language	English (US)
Pages (from-to)	EL334-EL338
Journal	Journal of the Acoustical Society of America
Volume	130
Issue number	5
DOIs	https://doi.org/10.1121/1.3646024
State	Published - Nov 2011

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Acoustics and Ultrasonics

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10.1121/1.3646024

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title = "Three-dimensional impedance map analysis of rabbit liver",

abstract = "Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ± 1.3 and 7.0 ± 0.3 m for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.",

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note = "Funding Information: This work was supported by the U.S. National Institutes of Health (R01CA111289). The authors would like to acknowledge the technical assistance of Rita J. Miller, DVM.",

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AU - Pawlicki, Alexander D.

AU - Dapore, Alexander J.

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AU - O'Brien, William D.

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AB - Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ± 1.3 and 7.0 ± 0.3 m for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.

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Three-dimensional impedance map analysis of rabbit liver

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