Three-dimensional impedance map analysis of rabbit liver

Alexander D. Pawlicki, Alexander J. Dapore, Sandhya Sarwate, William D. O'Brien

Research output: Contribution to journalArticlepeer-review


Three-dimensional impedance maps (3DZMs) are computational models of acoustic impedance of tissue constructed from histology images. 3DZMs can be analyzed to estimate model-based quantitative ultrasound parameters such as effective scatterer diameter (ESD). In this study, 3DZMs were constructed from normal and fatty rabbit livers. Estimates of ESD were made using the fluid-filled sphere scattering model. Weighting toward smaller scatterer sizes produced ESD estimates of 7.5 ± 1.3 and 7.0 ± 0.3 m for normal and fatty liver, respectively, approximately the size of a liver cell nucleus. This suggests the nucleus could be a primary source of scattering in liver.

Original languageEnglish (US)
Pages (from-to)EL334-EL338
JournalJournal of the Acoustical Society of America
Issue number5
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics


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