Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes

P. C. Roberts, Z. Lu, G. F. Kutish, D. L. Rock

Research output: Contribution to journalArticlepeer-review

Abstract

Nucleotide sequencing of the right end of the SalIj fragment of the highly virulent Malawi Lil 20/1 strain of African swine fever virus (ASFV) has revealed three adjacent genes with similarity to: serine-threonine protein kinases; members of the putative helicase superfamily SF2; and the vaccinia virus 56 kDa abortive late protein. All three genes are transcribed to the left with respect to the orientation of the ASFV genome. Gene L19IL predicts a protein similar to serine-threonine protein kinases including vaccinia virus gene B1R. Gene L19KL predicts a protein that is likely to be a nucleic acid-dependent ATPase, as it has similarity to both the poxvirus 70 kDa early transcription factor subunit and the poxvirus nucleoside triphosphatase I gene. Gene L19LL has extensive similarity to the vaccinia virus 56 kDa abortive late protein.

Original languageEnglish (US)
Pages (from-to)331-342
Number of pages12
JournalArchives of Virology
Volume132
Issue number3-4
DOIs
StatePublished - Sep 1993
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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