Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging

Chathuranga S.L. Rathnamalala; Nicholas W. Pino; Bailey S. Herring; Mattea Hooper; Steven R. Gwaltney; Jefferson Chan; Colleen N. Scott

doi:10.1021/acs.orglett.1c02862

Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging

Chathuranga S.L. Rathnamalala, Nicholas W. Pino, Bailey S. Herring, Mattea Hooper, Steven R. Gwaltney, Jefferson Chan, Colleen N. Scott

Research output: Contribution to journal › Article › peer-review

Abstract

Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.

Original language	English (US)
Pages (from-to)	7640-7644
Number of pages	5
Journal	Organic Letters
Volume	23
Issue number	19
DOIs	https://doi.org/10.1021/acs.orglett.1c02862
State	Published - Oct 1 2021

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.1c02862

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title = "Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging",

abstract = "Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.",

author = "Rathnamalala, {Chathuranga S.L.} and Pino, {Nicholas W.} and Herring, {Bailey S.} and Mattea Hooper and Gwaltney, {Steven R.} and Jefferson Chan and Scott, {Colleen N.}",

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T1 - Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging

AU - Rathnamalala, Chathuranga S.L.

AU - Pino, Nicholas W.

AU - Herring, Bailey S.

AU - Hooper, Mattea

AU - Gwaltney, Steven R.

AU - Chan, Jefferson

AU - Scott, Colleen N.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.

AB - Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.

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Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging

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