Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging

Chathuranga S.L. Rathnamalala, Nicholas W. Pino, Bailey S. Herring, Mattea Hooper, Steven R. Gwaltney, Jefferson Chan, Colleen N. Scott

Research output: Contribution to journalArticlepeer-review


Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.

Original languageEnglish (US)
Pages (from-to)7640-7644
Number of pages5
JournalOrganic Letters
Issue number19
StatePublished - Oct 1 2021

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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