@article{258d6d2d05f54a31a4a4c5b0bdc373f7,
title = "Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation",
abstract = "Hippocampal CA1 neurons generate single spikes and stereotyped bursts of spikes. However, it is unclear how individual neurons dynamically switch between these output modes and whether these two spiking outputs relay distinct information. We performed extracellular recordings in spatially navigating rats and cellular voltage imaging and optogenetics in awake mice. We found that spike bursts are preferentially linked to cellular and network theta rhythms (3–12 Hz) and encode an animal's position via theta phase precession, particularly as animals are entering a place field. In contrast, single spikes exhibit additional coupling to gamma rhythms (30–100 Hz), particularly as animals leave a place field. Biophysical modeling suggests that intracellular properties alone are sufficient to explain the observed input frequency-dependent spike coding. Thus, hippocampal neurons regulate the generation of bursts and single spikes according to frequency-specific network and intracellular dynamics, suggesting that these spiking modes perform distinct computations to support spatial behavior.",
keywords = "CP: Neuroscience, SomArchon, complex spikes, neural oscillations, optogenetics, bursts, place fields, plateau potentials, spatial navigation, subthreshold voltage, voltage imaging",
author = "Eric Lowet and Sheehan, {Daniel J.} and Ulises Chialva and {De Oliveira Pena}, Rodrigo and Mount, {Rebecca A.} and Sheng Xiao and Zhou, {Samuel L.} and Tseng, {Hua an} and Howard Gritton and Sanaya Shroff and Krishnakanth Kondabolu and Cyrus Cheung and Yangyang Wang and Piatkevich, {Kiryl D.} and Boyden, {Edward S.} and Jerome Mertz and Hasselmo, {Michael E.} and Rotstein, {Horacio G.} and Xue Han",
note = "X.H. acknowledges funding from NIH ( R01NS115797 , R01NS109794 , and R01NS119483 ) and NSF ( CBET-1848029 ). X.H. and E.S.B. acknowledge NIH R01MH122971 . X.H. and H.G.R acknowledge NSF 2002971-DIOS . E.L. acknowledges funding from Boston University Center for Systems Neuroscience . R.A.M. acknowledges NIH NRSA fellowship ( F31MH123008 ). X.H. acknowledges funding from NIH (R01NS115797, R01NS109794, and R01NS119483) and NSF (CBET-1848029). X.H. and E.S.B. acknowledge NIH R01MH122971. X.H. and H.G.R acknowledge NSF 2002971-DIOS. E.L. acknowledges funding from Boston University Center for Systems Neuroscience. R.A.M. acknowledges NIH NRSA fellowship (F31MH123008). E.L. and X.H. conceived the project. E.L. performed all imaging experiments with support from S.L.Z. K.K. S.X. H.G. S.S. and C.C. E.L. analyzed the data. E.L. R.A.M. and H.G. prepared the animals for the experiments. D.J.S. and M.E.H performed rat tetrode recordings. E.L. U.C. R.D.O.P. and H.G.R. performed biophysical simulations. Y.W. K.D.P. and E.S.B. generated pAAV-Syn-SomArchon-mTagBFP2-p2A-CoChR-Kv2.1 plasmid. X.H. supervised the study. E.L. and X.H. wrote the manuscript. All authors edited the manuscript. The authors declare no competing interests.",
year = "2023",
month = aug,
day = "29",
doi = "10.1016/j.celrep.2023.112906",
language = "English (US)",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}