Abstract
Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-210 |
| Number of pages | 10 |
| Journal | Cancer Prevention Research |
| Volume | 12 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2019 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer. / Cam, Anthony; Oyirifi, Ashley B.; Liu, Yunxian; Haschek, Wanda M.; Iwaniec, Urszula T.; Turner, Russell T.; Engeseth, Nicki J.; Helferich, William G.
In: Cancer Prevention Research, Vol. 12, No. 4, 01.04.2019, p. 201-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer
AU - Cam, Anthony
AU - Oyirifi, Ashley B.
AU - Liu, Yunxian
AU - Haschek, Wanda M.
AU - Iwaniec, Urszula T.
AU - Turner, Russell T.
AU - Engeseth, Nicki J.
AU - Helferich, William G.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.
AB - Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.
UR - http://www.scopus.com/inward/record.url?scp=85064061656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064061656&partnerID=8YFLogxK
U2 - 10.1158/1940-6207.CAPR-18-0220
DO - 10.1158/1940-6207.CAPR-18-0220
M3 - Article
C2 - 30885926
AN - SCOPUS:85064061656
VL - 12
SP - 201
EP - 210
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 4
ER -