Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer

Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.