Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer

Anthony Cam, Ashley B. Oyirifi, Yunxian Liu, Wanda M. Haschek, Urszula T. Iwaniec, Russell T. Turner, Nicki J. Engeseth, William G. Helferich

Research output: Contribution to journalArticle

Abstract

Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalCancer Prevention Research
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2019

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Oils
Breast Neoplasms
Neoplasm Metastasis
Lipids
Lung
Soybean Oil
Triglycerides
Unsaturated Dietary Fats
RNA Sequence Analysis
Neoplasms
Liver
Health
Polymers
Diet
Gene Expression
Food

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer. / Cam, Anthony; Oyirifi, Ashley B.; Liu, Yunxian; Haschek, Wanda M.; Iwaniec, Urszula T.; Turner, Russell T.; Engeseth, Nicki J.; Helferich, William G.

In: Cancer Prevention Research, Vol. 12, No. 4, 01.04.2019, p. 201-210.

Research output: Contribution to journalArticle

Cam, Anthony ; Oyirifi, Ashley B. ; Liu, Yunxian ; Haschek, Wanda M. ; Iwaniec, Urszula T. ; Turner, Russell T. ; Engeseth, Nicki J. ; Helferich, William G. / Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer. In: Cancer Prevention Research. 2019 ; Vol. 12, No. 4. pp. 201-210.
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