TY - JOUR
T1 - Thermally abused frying oil potentiates metastasis to lung in a murine model of late-stage breast cancer
AU - Cam, Anthony
AU - Oyirifi, Ashley B.
AU - Liu, Yunxian
AU - Haschek, Wanda M.
AU - Iwaniec, Urszula T.
AU - Turner, Russell T.
AU - Engeseth, Nicki J.
AU - Helferich, William G.
N1 - Funding Information:
This work was supported by the NIH [P50AT006268] (to W.G. Helferich) from the National Center for Complementary and Integrative Health (NCCIH), the Office of Dietary Supplements (ODS), the National Cancer Institute (NCI), and National Institute of Environmental Health Sciences Grant T32 ES007326 (to A.B. Oyirifi). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCCIH, ODS, NCI, or the NIH.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.
AB - Deep-frying is a popular form of food preparation study used a late-stage breast cancer murine model used globally and throughout in the United States. and in vivo bioluminescent imaging to monitor pro-Each time dietary oils are heated to deep-frying tem-gression of metastasis of 4T1 tumor cells in animals peratures, they undergo chemical alterations that consuming fresh soybean oil (SBO) and a thermally result in a new matrix of lipid structures. These lipid abused frying oil (TAFO). Bioluminescent and histo-products include triglyceride dimers, polymers, oxi-logic examinations demonstrated that TAFO con-dized triglycerides, and cyclic monomers, which sumption resulted in a marked increase of metastatic raises nutritional concerns about associations lung tumor formation compared to SBO consump-between these lipid products and heightened health tion. Further, in animals consuming the TAFO treat-risks. Reports of associations between thermally ment diet, metastatic tumors in the lung displayed a abused frying oil and deleterious health outcomes 1.4-fold increase in the Ki-67 marker of cellular currently exist, yet there is little information concern-proliferation and RNA-sequencing analysis of the ing the effects of thermally abused frying oil con-hepatic tissue revealed a dietary-induced modulation sumption and the progression of breast cancer. This of gene expression in the liver.
UR - http://www.scopus.com/inward/record.url?scp=85064061656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064061656&partnerID=8YFLogxK
U2 - 10.1158/1940-6207.CAPR-18-0220
DO - 10.1158/1940-6207.CAPR-18-0220
M3 - Article
C2 - 30885926
AN - SCOPUS:85064061656
VL - 12
SP - 201
EP - 210
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 4
ER -