Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Tae Joon Won; Bongjoon Kim; Yunjung Lee; Joon Seok Bang; Eun Seul Oh; Jong Sun Yoo; Kyeong Eun Hyung; Joowon Yoon; Sehee Hwang; Eon Sub Park; So Young Park; Kwang Woo Hwang

doi:10.1016/j.cellimm.2012.05.013

Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Tae Joon Won, Bongjoon Kim, Yunjung Lee, Joon Seok Bang, Eun Seul Oh, Jong Sun Yoo, Kyeong Eun Hyung, Joowon Yoon, Sehee Hwang, Eon Sub Park, So Young Park, Kwang Woo Hwang

Research output: Contribution to journal › Article › peer-review

Abstract

Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.

Original language	English (US)
Pages (from-to)	49-57
Number of pages	9
Journal	Cellular Immunology
Volume	277
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cellimm.2012.05.013
State	Published - May 2012
Externally published	Yes

Keywords

Atopic dermatitis
Axillary lymph node
House-dust mite
Kimchi
Lactobacillus plantarum CJLP133
NC/Nga mouse
Regulatory T cells
Type 1 helper T cells

ASJC Scopus subject areas

Immunology

Online availability

10.1016/j.cellimm.2012.05.013

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title = "Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice",

abstract = "Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.",

keywords = "Atopic dermatitis, Axillary lymph node, House-dust mite, Kimchi, Lactobacillus plantarum CJLP133, NC/Nga mouse, Regulatory T cells, Type 1 helper T cells",

author = "Won, {Tae Joon} and Bongjoon Kim and Yunjung Lee and Bang, {Joon Seok} and Oh, {Eun Seul} and Yoo, {Jong Sun} and Hyung, {Kyeong Eun} and Joowon Yoon and Sehee Hwang and Park, {Eon Sub} and Park, {So Young} and Hwang, {Kwang Woo}",

year = "2012",

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language = "English (US)",

volume = "277",

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AU - Won, Tae Joon

AU - Kim, Bongjoon

AU - Lee, Yunjung

AU - Bang, Joon Seok

AU - Oh, Eun Seul

AU - Yoo, Jong Sun

AU - Hyung, Kyeong Eun

AU - Yoon, Joowon

AU - Hwang, Sehee

AU - Park, Eon Sub

AU - Park, So Young

AU - Hwang, Kwang Woo

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AB - Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.

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KW - Axillary lymph node

KW - House-dust mite

KW - Kimchi

KW - Lactobacillus plantarum CJLP133

KW - NC/Nga mouse

KW - Regulatory T cells

KW - Type 1 helper T cells

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Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Abstract

Keywords

ASJC Scopus subject areas

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