Abstract

Bioactive peptides are important therapeutic drugs, yet conventional methods of peptide synthesis are challenged to meet increasing demand. We developed a novel and efficient means of metabolic engineering: therapeutic peptide production in Drosophila and as a proof of concept, we demonstrate production of fully matured human insulin. This in vivo system offers an innovative means to produce valuable bioactive peptides for therapies, its inherent flexibility facilitates drug development, and its ease of producing fully processed peptides simplifies metabolic engineering of new peptide products.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalPeptides
Volume36
Issue number2
DOIs
StatePublished - Aug 1 2012

Keywords

  • DIMM
  • Drosophila
  • Insulin
  • Theraputic peptides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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