The yeast ATP-binding cassette (ABC) transporter Ycf1p enhances the recruitment of the soluble SNARE Vam7p to vacuoles for efficient membrane fusion

Terry L. Sasser, Gus Lawrence, Surya Karunakaran, Christopher Brown, Rutilio A. Fratti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Ycf1p is a ABCC transporter that is localized to the vacuole and that was initially characterized as a cadmium transporter. Results: Deletion of YCF1 inhibits vacuole fusion in part by excluding the soluble SNARE Vam7p. Conclusion: The vacuole fusion machinery requires Ycf1p function for efficient fusion. Significance: This is the first report that an ABCC protein affects fusion through the recruitment of a SNARE.

Original languageEnglish (US)
Pages (from-to)18300-18310
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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