@article{c1c85eceb8ce4dabbd5496398ad7070e,
title = "The validity, stability, and utility of measuring uric acid in saliva",
abstract = "Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA. Materials & methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Using longitudinal data from young adults (n = 182), we examined salivary UA stability. Results: We found robust positive serum-saliva correlations for UA. UA and adiponectin were inversely related in serum and saliva. Salivary UA was relatively stable; 62-66% of variance could be attributed to a latent trait-like component. Conclusion: Salivary UA may be an important biomarker indexing health and disease risk.",
keywords = "adiponectin, biomarker, body mass index, C-reactive protein, latent state-trait modeling, saliva, serum, uric acid",
author = "Riis, {Jenna L.} and Bryce, {Crystal I.} and Matin, {Marla J.} and Stebbins, {John L.} and Olga Kornienko and {Van Huisstede}, Lauren and Granger, {Douglas A.}",
note = "Funding Information: This work was supported by a formative research project grant from the National Children's Study (NICHD research project LOI2-BIO-19, PI Douglas Granger); a seed grant from the Herberger School of Music at ASU; and reagents were graciously donated by Salimetrics LLC (CA, USA). O Kornienko was supported in part by National Institutes of Health Loan Repayment Award (L30 DA042448) Funding Information: This work was supported by a formative research project grant from the National Children{\textquoteright}s Study (NICHD research project LOI2-BIO-19, PI Douglas Granger); a seed grant from the Herberger School of Music at ASU; and reagents were graciously donated by Salimetrics LLC (CA, USA). O Kornienko was supported in part by National Institutes of Health Loan Repayment Award (L30 DA042448). In the interest of full disclosure, DA Granger is founder and chief scientific and strategy advisor at Salimetrics LLC and Salivabio LLC and these relationships are managed by the policies of the committees on conflict of interest at the Johns Hopkins University School of Medicine and the University of California at Irvine. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd.",
year = "2018",
month = jun,
doi = "10.2217/bmm-2017-0336",
language = "English (US)",
volume = "12",
pages = "583--596",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Taylor and Francis Ltd.",
number = "6",
}