The unifying role of cytoskeletal prestress in micromechanics of the adherent cell

D. Stamenovic; I. M. Tolic-Nørrelykke; J. J. Fredberg; Ning Wang

The unifying role of cytoskeletal prestress in micromechanics of the adherent cell

D. Stamenovic, I. M. Tolic-Nørrelykke, J. J. Fredberg, Ning Wang

Research output: Contribution to journal › Article › peer-review

Abstract

We measured cytoskeletal prestress and stiffness in cultured airway smooth muscle cells treated with graded doses of histamine and isoproterenol, and with colchicine. The stiffness increased in proportion with increasing prestress. This feature is the hallmark of systems known as stress-supported structures. In addition, microtubules balanced a substantial, but relatively small fraction of the prestress.

Original language	English (US)
Pages (from-to)	1466-1467
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	2
State	Published - 2002
Externally published	Yes

Keywords

Cytoskeleton
Microtubules
Prestress
Tensegrity

ASJC Scopus subject areas

Bioengineering

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AU - Tolic-Nørrelykke, I. M.

AU - Fredberg, J. J.

AU - Wang, Ning

PY - 2002

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KW - Microtubules

KW - Prestress

KW - Tensegrity

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The unifying role of cytoskeletal prestress in micromechanics of the adherent cell

Abstract

Keywords

ASJC Scopus subject areas

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