The ultrastructure of collagen in the dermis of tight-skin (Tsk) mutant mice

D. N. Menton, R. A. Hess

Research output: Contribution to journalArticlepeer-review

Abstract

A recently discovered dominant mutation in C37/B10 mice called tight-skin (Tsk) results in hypertrophy of certain collagenous tissues including the dermis and hypodermis. The skin of heterozygotes (Tsk/+) is indurated and substantially stiffer than that of the normal animals (+/+). In this study, an electron microscopical comparison of the skin of these animals revealed that the fibrous architecture of the hypertrophic reticular dermis of Tsk/+ mice is more disorganized than that of the +/+ mice and in many areas, the collagen fibrils are more densely packed. The abundance of fibroblasts with distended endoplasmic reticulum in both the dermis and hypodermis of Tsk/+ mice is consistent with increased collagen synthesis. Several of the changes in the dermis and hypodermis of the Tsk/+ mice are similar to changes reported in sclerodermatous skin of man. Surprisingly, an apparent abnormality in the morphology of some of collagen fibrils in the skin of Tsk/+ mice was found to be at least as prevalent in the 'normal' +/+ mice. The reticular dermis of both animals contains scattered fibrils which are much larger in diameter than normal and often have a twisted appearance resulting from either helical grooves in the surface of the fibril or discrete branches which twist about one another.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalJournal of Investigative Dermatology
Volume74
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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