The thalamotectal system: An ancient projection for modulating the auditory midbrain

Mili B. Patel, Stacy Sons, Luye Yang, Gehad A. Taha, Daniel A. Llano, Alexandria M H Lesicko, Georgiy Yudintsev

Research output: Contribution to journalConference article

Abstract

Descending projections from the thalamus and related structures to the tectum are evolutionarily conserved. Here we characterize basic properties of the mouse auditory thalamotectal pathway and compare them to a homologous pathway in the frog: a species that does not contain a neocortex or an additional corticocollicular pathway. Mouse auditory thalamotectal neurons were found to not stain for the calcium-binding markers typically found in the mammalian thalamus. However, many tectal-projecting cells from the brachium of the inferior colliculus were observed to be GABAergic. In addition, mouse thalamotectal neurons in vitro were found to not demonstrate the low-threshold bursting that is commonly found in thalamocortical neurons. The latter two properties - descending inhibition and lack of bursting - are also found in the frog thalamotectal system. However, these properties are not found in mammalian neocortically-projecting thalamic neurons. Given the divergence of amphibians and mammals hundreds of millions years ago, these data suggest that the thalamotectal projection represents an ancient pathway for providing top-down modulation of acoustic responses in the auditory midbrain. This work is presented in homage to Professor Albert Feng, who pioneered a comparative approach to understanding the auditory system, particularly with respect to the auditory midbrain in amphibians and mammals.

Original languageEnglish (US)
Article number010004
JournalProceedings of Meetings on Acoustics
Volume25
Issue number1
DOIs
StatePublished - Nov 2 2015
Event170th Meeting of the Acoustical Society of America 2015 - Jacksonville, United States
Duration: Nov 2 2015Nov 6 2015

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neurons
thalamus
projection
mice
frogs
mammals
markers
calcium
divergence
modulation
thresholds
acoustics
cells

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

The thalamotectal system : An ancient projection for modulating the auditory midbrain. / Patel, Mili B.; Sons, Stacy; Yang, Luye; Taha, Gehad A.; Llano, Daniel A.; Lesicko, Alexandria M H; Yudintsev, Georgiy.

In: Proceedings of Meetings on Acoustics, Vol. 25, No. 1, 010004, 02.11.2015.

Research output: Contribution to journalConference article

Patel, Mili B. ; Sons, Stacy ; Yang, Luye ; Taha, Gehad A. ; Llano, Daniel A. ; Lesicko, Alexandria M H ; Yudintsev, Georgiy. / The thalamotectal system : An ancient projection for modulating the auditory midbrain. In: Proceedings of Meetings on Acoustics. 2015 ; Vol. 25, No. 1.
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