The TEM characterization of the lamellar structure of osteoporotic human trabecular bone

Matthew Aaron Rubin, Iwona Jasiuk

Research output: Contribution to journalReview articlepeer-review

Abstract

The lamellar structure of osteoporotic human trabecular bone was characterized experimentally by means of transmission electron microscopy (TEM). More specifically, the TEM was used to determine if trabecular bone exhibits similar lamellar structural motifs as cortical bone by analyzing unmineralized, mineralized and demineralized bone, and to study the influence of the osteocyte network on the lamellar structure of osteoporotic trabecular bone. Comparison with normal trabecular bone is included. This paper summarizes partial results of a larger study, which addressed the characterization of the hierarchical structure of normal versus osteoporotic human trabecular bone [Rubin, M.A., 2001. Multiscale characterization of the ultrastructure of trabecular bone in osteoporotic and normal humans and in two inbred strains of mice. MS Thesis, Georgia Institute of Technology.] at several structural scales.

Original languageEnglish (US)
Pages (from-to)653-664
Number of pages12
JournalMicron
Volume36
Issue number7-8
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Keywords

  • Lamellar level
  • Osteoporosis
  • Trabecular bone
  • Transmission electron microscopy

ASJC Scopus subject areas

  • Cell Biology
  • Materials Science(all)
  • Instrumentation
  • Biotechnology

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