TY - JOUR
T1 - The tandem cycloaddition chemistry of nitroalkenes
AU - Denmark, Scott E.
AU - Schnute, Mark E.
AU - Thorarensen, Atli
AU - Middleton, Donald S.
AU - Stolle, Andreas
N1 - Funding Information:
Acknowledgment. We are grateful to the National Institutes of Health (GM 30938) for support of this research. M.E.S. thanks the Organic Division of the ACS for a graduate fellowship. D.S.M. thanks Merck, Sharp and Dohme for a postdoctoral fellowship. AS. thanks the Alexander von Humbodlt foundation for a Feodor Lynen fellowship.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Nitroalkenes have proven to be extremely versatile 4π-components in heterodiene [4+2]-cycloadditions. Our efforts in this area have been intensively methodological with focus on the reaction scope, mechanism, stereoselectivity and transformations of the cycloadducts. The three modes of tandem inter [4+2]/ intra [3+2] cycloaddition, fused, spiro and bridged have been documented. An efficient and highly selective synthesis of (−)-hastanecine has been completed.
AB - Nitroalkenes have proven to be extremely versatile 4π-components in heterodiene [4+2]-cycloadditions. Our efforts in this area have been intensively methodological with focus on the reaction scope, mechanism, stereoselectivity and transformations of the cycloadducts. The three modes of tandem inter [4+2]/ intra [3+2] cycloaddition, fused, spiro and bridged have been documented. An efficient and highly selective synthesis of (−)-hastanecine has been completed.
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U2 - 10.1351/pac199466102041
DO - 10.1351/pac199466102041
M3 - Article
AN - SCOPUS:0003516785
SN - 0033-4545
VL - 66
SP - 2041
EP - 2044
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
IS - 10-11
ER -