The structure of mammalian fatty acid synthase turned back to front

Research output: Contribution to journalShort survey

Abstract

On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid synthase is a head-to-head dimer rather than the head-to-tail dimer depicted in textbooks. This has important ramifications for the mechanisms of other multifunctional enzymes such as polyketide synthases [2].

Original languageEnglish (US)
Pages (from-to)1601-1602
Number of pages2
JournalChemistry and Biology
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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