Abstract
Chemotaxis--the directed movement of cells in a gradient of chemoattractant--is essential for neutrophils to crawl to sites of inflammation and infection and for Dictyostelium discoideum (D. discoideum) to aggregate during morphogenesis. Chemoattractant-induced activation of spatially localized cellular signals causes cells to polarize and move toward the highest concentration of the chemoattractant. Extensive studies have been devoted to achieving a better understanding of the mechanism(s) used by a neutrophil to choose its direction of polarity and to crawl effectively in response to chemoattractant gradients. Recent technological advances are beginning to reveal many fascinating details of the intracellular signaling components that spatially direct the cytoskeleton of neutrophils and D. discoideum and the complementary mechanisms that make the cell's front distinct from its back.
| Original language | English (US) |
|---|---|
| Journal | Cold Spring Harbor Perspectives in Biology |
| Volume | 1 |
| Issue number | 4 |
| State | Published - Oct 2009 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The signaling mechanisms underlying cell polarity and chemotaxis. / Wang, Fei.
In: Cold Spring Harbor Perspectives in Biology, Vol. 1, No. 4, 10.2009.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The signaling mechanisms underlying cell polarity and chemotaxis.
AU - Wang, Fei
PY - 2009/10
Y1 - 2009/10
N2 - Chemotaxis--the directed movement of cells in a gradient of chemoattractant--is essential for neutrophils to crawl to sites of inflammation and infection and for Dictyostelium discoideum (D. discoideum) to aggregate during morphogenesis. Chemoattractant-induced activation of spatially localized cellular signals causes cells to polarize and move toward the highest concentration of the chemoattractant. Extensive studies have been devoted to achieving a better understanding of the mechanism(s) used by a neutrophil to choose its direction of polarity and to crawl effectively in response to chemoattractant gradients. Recent technological advances are beginning to reveal many fascinating details of the intracellular signaling components that spatially direct the cytoskeleton of neutrophils and D. discoideum and the complementary mechanisms that make the cell's front distinct from its back.
AB - Chemotaxis--the directed movement of cells in a gradient of chemoattractant--is essential for neutrophils to crawl to sites of inflammation and infection and for Dictyostelium discoideum (D. discoideum) to aggregate during morphogenesis. Chemoattractant-induced activation of spatially localized cellular signals causes cells to polarize and move toward the highest concentration of the chemoattractant. Extensive studies have been devoted to achieving a better understanding of the mechanism(s) used by a neutrophil to choose its direction of polarity and to crawl effectively in response to chemoattractant gradients. Recent technological advances are beginning to reveal many fascinating details of the intracellular signaling components that spatially direct the cytoskeleton of neutrophils and D. discoideum and the complementary mechanisms that make the cell's front distinct from its back.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957259884&partnerID=8YFLogxK
M3 - Review article
C2 - 20066099
AN - SCOPUS:77957259884
VL - 1
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
SN - 1943-0264
IS - 4
ER -