The Schotten-Baumann reaction as an aid to the analysis of polar compounds: Application to the determination of tris(hydroxymethyl)aminomethane (THAM)

Steven Robert Blanke, R. V. Blanke

Research output: Contribution to journalArticlepeer-review

Abstract

The separation of polar, low molecular weight, water-soluble compounds from specimens prior to quantitation has long been a problem in analytical toxicology. Others have successfully used in situ derivatization, prior to extraction, to resolve this problem. An application of the Schotten-Baumann reaction leading to a simple extraction of tris(hydroxymethyl)aminomethane (THAM) followed by HPLC is presented. This may be a generic approach to the analysis of other polyhydroxy, water-soluble compounds.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalJournal of Analytical Toxicology
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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