Abstract
The separation of polar, low molecular weight, water-soluble compounds from specimens prior to quantitation has long been a problem in analytical toxicology. Others have successfully used in situ derivatization, prior to extraction, to resolve this problem. An application of the Schotten-Baumann reaction leading to a simple extraction of tris(hydroxymethyl)aminomethane (THAM) followed by HPLC is presented. This may be a generic approach to the analysis of other polyhydroxy, water-soluble compounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-233 |
| Number of pages | 3 |
| Journal | Journal of Analytical Toxicology |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine