The role of pyocyanin in Pseudomonas aeruginosa infection

Gee W. Lau, Daniel J. Hassett, Huimin Ran, Fansheng Kong

Research output: Contribution to journalReview article

Abstract

Pyocyanin (PCN) is a blue redox-active secondary metabolite that is produced by Pseudomonas aeruginosa. PCN is readily recovered in large quantities in sputum from patients with cystic fibrosis who are infected by P. aeruginosa. Despite in vitro studies demonstrating that PCN interferes with multiple cellular functions, its importance during clinical infection is uncertain. This is partially caused by the difficulty in defining the contribution of PCN among the numerous virulence factors produced by P. aeruginosa during infection. In addition, few cellular pathways that are affected by PCN are known. This review briefly highlights recent advances that might clarify the role of PCN in P. aeruginosa pathogenesis.

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
JournalTrends in Molecular Medicine
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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