TY - JOUR
T1 - The Role of Bisphosphonates in the Management of Patients That Have Cancer
AU - Fan, Timothy M.
PY - 2007/11
Y1 - 2007/11
N2 - Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
AB - Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
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U2 - 10.1016/j.cvsm.2007.08.002
DO - 10.1016/j.cvsm.2007.08.002
M3 - Review article
C2 - 17950884
AN - SCOPUS:35348818698
SN - 0195-5616
VL - 37
SP - 1091
EP - 1110
JO - Veterinary Clinics of North America - Small Animal Practice
JF - Veterinary Clinics of North America - Small Animal Practice
IS - 6
ER -