Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.

Original languageEnglish (US)
Pages (from-to)1091-1110
Number of pages20
JournalVeterinary Clinics of North America - Small Animal Practice
Issue number6
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Small Animals


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