Abstract
Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1091-1110 |
| Number of pages | 20 |
| Journal | Veterinary Clinics of North America - Small Animal Practice |
| Volume | 37 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2007 |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
The Role of Bisphosphonates in the Management of Patients That Have Cancer. / Fan, Timothy M.
In: Veterinary Clinics of North America - Small Animal Practice, Vol. 37, No. 6, 01.11.2007, p. 1091-1110.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Role of Bisphosphonates in the Management of Patients That Have Cancer
AU - Fan, Timothy M
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
AB - Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.
UR - http://www.scopus.com/inward/record.url?scp=35348818698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35348818698&partnerID=8YFLogxK
U2 - 10.1016/j.cvsm.2007.08.002
DO - 10.1016/j.cvsm.2007.08.002
M3 - Review article
C2 - 17950884
AN - SCOPUS:35348818698
VL - 37
SP - 1091
EP - 1110
JO - Veterinary Clinics of North America - Small Animal Practice
JF - Veterinary Clinics of North America - Small Animal Practice
SN - 0195-5616
IS - 6
ER -