The Role of Bisphosphonates in the Management of Patients That Have Cancer

Research output: Contribution to journalReview article

Abstract

Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.

Original languageEnglish (US)
Pages (from-to)1091-1110
Number of pages20
JournalVeterinary Clinics of North America - Small Animal Practice
Volume37
Issue number6
DOIs
StatePublished - Nov 1 2007

Fingerprint

Diphosphonates
bones
osteoclasts
neoplasms
pharmacology
pets
mechanism of action
Neoplasms
physicochemical properties
apoptosis
concentrates
adverse effects
cats
dogs
Bone Remodeling
Pets
Osteoclasts
Cats
Biomarkers
Pharmacology

ASJC Scopus subject areas

  • veterinary(all)

Cite this

The Role of Bisphosphonates in the Management of Patients That Have Cancer. / Fan, Timothy M.

In: Veterinary Clinics of North America - Small Animal Practice, Vol. 37, No. 6, 01.11.2007, p. 1091-1110.

Research output: Contribution to journalReview article

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