The Role of Bisphosphonates in the Management of Patients That Have Cancer

Timothy M Fan

doi:10.1016/j.cvsm.2007.08.002

The Role of Bisphosphonates in the Management of Patients That Have Cancer

Research output: Contribution to journal › Review article

Abstract

Bisphosphonates are pharmacologic agents widely used in people for managing pathologic bone resorptive conditions. Based on their physicochemical properties, bisphosphonates concentrate within areas of active bone remodeling and induce osteoclast apoptosis. Appropriate use of bisphosphonates for treating companion animals requires a thorough understanding of how bisphosphonates exert their biologic effects. This review article highlights general properties of bisphosphonates, including their pharmacology, mechanisms of action, adverse side effects, anticancer mechanisms, surrogate markers for assessing response, and potential clinical utility for treating dogs and cats diagnosed with malignant skeletal tumors.

Original language	English (US)
Pages (from-to)	1091-1110
Number of pages	20
Journal	Veterinary Clinics of North America - Small Animal Practice
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.cvsm.2007.08.002
State	Published - Nov 1 2007

ASJC Scopus subject areas

veterinary(all)

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Fan, T. M. (2007). The Role of Bisphosphonates in the Management of Patients That Have Cancer. Veterinary Clinics of North America - Small Animal Practice, 37(6), 1091-1110. https://doi.org/10.1016/j.cvsm.2007.08.002

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