The relationships between steroid molecular structure and cell growth

D. E. Buetow; B. H. Levedahl

doi:10.1016/0003-9861(60)90364-7

The relationships between steroid molecular structure and cell growth

D. E. Buetow
, B. H. Levedahl

Research output: Contribution to journal › Article › peer-review

Abstract

The growth rate of the chlorotic, free-living flagellate Euglena gracilis var. bacillaris (streptomycin-bleached) is accelerated by androgenic, estrogenic, and adrenal steroid hormones at concentrations as low as 10^-4 mg. steroid/l. of culture medium. Progesterone, pregnanediol, and cholesterol did not affect the growth rate of Euglena cells at any concentration used. The structural features necessary for the action of the steroid appear to be either a ketone or hydroxyl grouping at carbons 3 and/or 17 of the nucleus and an over-all planar configuration of the molecule. The data infer that in this growth-accelerating action any role other than that of a catalyst is unlikely for the steroid molecule.

Original language	English (US)
Pages (from-to)	34-41
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/0003-9861(60)90364-7
State	Published - Jan 1960
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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10.1016/0003-9861(60)90364-7

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AB - The growth rate of the chlorotic, free-living flagellate Euglena gracilis var. bacillaris (streptomycin-bleached) is accelerated by androgenic, estrogenic, and adrenal steroid hormones at concentrations as low as 10-4 mg. steroid/l. of culture medium. Progesterone, pregnanediol, and cholesterol did not affect the growth rate of Euglena cells at any concentration used. The structural features necessary for the action of the steroid appear to be either a ketone or hydroxyl grouping at carbons 3 and/or 17 of the nucleus and an over-all planar configuration of the molecule. The data infer that in this growth-accelerating action any role other than that of a catalyst is unlikely for the steroid molecule.

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The relationships between steroid molecular structure and cell growth

Abstract

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