TY - JOUR
T1 - The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
AU - Zhang, Xing
AU - Flaws, Jodi A.
AU - Spinella, Michael J.
AU - Irudayaraj, Joseph
N1 - Funding Information:
This research was partially funded by the External Research Board, OVCRI, University of Illinois at Urbana-Champaign; NIEHS, grant number R01ES034112-01A1.
Funding Information:
The authors thank and extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through the Research Groups Program under grant number RGP 2/132/43 Data sets are available in this paper.
Publisher Copyright:
© 2022 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.
AB - Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.
KW - endocrine disrupting chemicals
KW - kidney diseases
KW - renal cell carcinoma
KW - disease mechanisms
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U2 - 10.3390/toxics11010032
DO - 10.3390/toxics11010032
M3 - Review article
C2 - 36668758
SN - 2305-6304
VL - 11
JO - Toxics
JF - Toxics
IS - 1
M1 - 32
ER -