The Puzzle of Regional Brain Activity in Depression and Anxiety: The Importance of Subtypes and Comorbidity

Wendy Heller, Jack B. Nitschke

Research output: Contribution to journalArticlepeer-review

Abstract

The literature on brain activity in depression and anxiety is reviewed with an emphasis on highlighting discrepancies and inconsistencies. In particular, anterior and posterior asymmetries have been reported for both depression and anxiety, but the magnitude and direction of these asymmetries has been variable. We propose that by identifying subtypes of depression and anxiety some of these inconsistencies can be explained. In addition, we review evidence suggesting that issues of comorbidity are important to consider in attempting to account for regional brain activity in depression and anxiety.

Original languageEnglish (US)
Pages (from-to)421-447
Number of pages27
JournalCognition and Emotion
Volume12
Issue number3
DOIs
StatePublished - May 1998

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

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