The proto-oncogene C-KIT maps to canid B-chromosomes

Alexander S. Graphodatsky, Anna V. Kukekova, Dmitry V. Yudkin, Vladimir A. Trifonov, Nadezhda V. Vorobieva, Violetta R. Beklemisheva, Polina L. Perelman, Daria A. Graphodatskaya, Lyudmila N. Trut, Fengtang Yang, Malcolm A. Ferguson-Smith, Gregory M. Acland, Gustavo D. Aguirre

Research output: Contribution to journalArticle

Abstract

Plant and animal karyotypes sometimes contain variable elements, that are referred to as additional or B-chromosomes. It is generally believed that B-chromosomes lack major genes and represent parasitic and selfish elements of a genome. Here we report, for the first time, the localization of a gene to B-chromosomes of mammals: red fox (Vulpes vulpes) and two subspecies of raccoon dog (Nyctereutes procyonoides). Identification of the proto-oncogene C-KIT on B-chromosomes of two Canidae species that diverged from a common ancestor more than 12.5 million years ago argues against the current view of B-chromosomes. Analyses of fox B-chromosomal C-KIT gene from a flow-sorted fox B-chromosome-specific library revealed the presence of intron-exon boundaries and high identity between sequenced regions of canine and fox B-chromosomal C-KIT copies. Identification of C-KIT gene on all B-chromosomes of two canid species provides new insight into the origin and evolution of supernumeraries and their potential role in the genome.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalChromosome Research
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • B-chromosome
  • C-KIT
  • Canidae
  • Oncogene

ASJC Scopus subject areas

  • Genetics

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    Graphodatsky, A. S., Kukekova, A. V., Yudkin, D. V., Trifonov, V. A., Vorobieva, N. V., Beklemisheva, V. R., Perelman, P. L., Graphodatskaya, D. A., Trut, L. N., Yang, F., Ferguson-Smith, M. A., Acland, G. M., & Aguirre, G. D. (2005). The proto-oncogene C-KIT maps to canid B-chromosomes. Chromosome Research, 13(2), 113-122. https://doi.org/10.1007/s10577-005-7474-9