Escherichia coli was recently reported to accumulate significant quantities of linoleic acid in stationary phase (H. Rabinowitch, D. D. Sklan, D. H. Chace, R. D. Stevens, and I. Fridovich, J. Bacteriol. 175:5324-5328, 1993). Since this finding would have considerable impact on the biochemical mechanisms of type II fatty acid synthases, we have attempted to confirm this observation. We found no evidence for the accumulation of linoleic acid in late-stationary-phase cultures of E. coli and conclude that the results of Rabinowitch et al. are artifactual.
ASJC Scopus subject areas
- Molecular Biology