The PmrAB system in Erwinia amylovora renders the pathogen more susceptible to polymyxin B and more resistant to excess iron

Sridevi Nakka; Mingsheng Qi; Youfu Zhao

doi:10.1016/j.resmic.2009.12.001

The PmrAB system in Erwinia amylovora renders the pathogen more susceptible to polymyxin B and more resistant to excess iron

Sridevi Nakka, Mingsheng Qi, Youfu Zhao

Crop Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron.

Original language	English (US)
Pages (from-to)	153-157
Number of pages	5
Journal	Research in Microbiology
Volume	161
Issue number	2
DOIs	https://doi.org/10.1016/j.resmic.2009.12.001
State	Published - Mar 2010

Keywords

Acidic pH
Iron
PmrAB system
Polymyxin B
Survival

ASJC Scopus subject areas

Microbiology
Molecular Biology

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title = "The PmrAB system in Erwinia amylovora renders the pathogen more susceptible to polymyxin B and more resistant to excess iron",

abstract = "The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron.",

keywords = "Acidic pH, Iron, PmrAB system, Polymyxin B, Survival",

author = "Sridevi Nakka and Mingsheng Qi and Youfu Zhao",

note = "Funding Information: This work was funded by the United States Department of Agriculture (USDA) – National Institute of Food and Agriculture (NIFA, Hatch project # Illu-802-317) , USDA-NIFA-Agriculture and Food Research Initiative project , and the Agricultural Experiment Station of Illinois .",

year = "2010",

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doi = "10.1016/j.resmic.2009.12.001",

language = "English (US)",

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AU - Nakka, Sridevi

AU - Qi, Mingsheng

AU - Zhao, Youfu

N1 - Funding Information: This work was funded by the United States Department of Agriculture (USDA) – National Institute of Food and Agriculture (NIFA, Hatch project # Illu-802-317) , USDA-NIFA-Agriculture and Food Research Initiative project , and the Agricultural Experiment Station of Illinois .

PY - 2010/3

Y1 - 2010/3

N2 - The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron.

AB - The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron.

KW - Acidic pH

KW - Iron

KW - PmrAB system

KW - Polymyxin B

KW - Survival

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The PmrAB system in Erwinia amylovora renders the pathogen more susceptible to polymyxin B and more resistant to excess iron

Abstract

Keywords

ASJC Scopus subject areas

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