The phylogenomic roots of translation

Derek Caetano-Anollés, Gustavo Caetano-Anollés

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The natural history of translation is mysterious but central to our understanding of the origin and evolution of biochemistry and life. tRNA is at the center of this biological process. Its interactions with aminoacyl-tRNA synthetase enzymes define the specificities of the genetic code and those with the ribosome their accurate biosynthetic interpretation. Here we review structural phylogenomic explorations of thousands of genomes and molecular structures that reveal a ‘metabolic-first’ origin of proteins, the early history of tRNA in interaction with cognate synthetase enzymes, the late appearance of a functional ribosome, and the co-evolutionary history of rRNA and proteins during ribosomal growth. We also discuss how the history of amino acid charging and codon specificities is embedded in tRNA and is encoded in genomes. Results uncover a hidden link between the genetic code and protein flexibility and suggest that tRNA molecules are building blocks of ribosomes and genomes. We make explicit the need to understand processes of molecular growth of macromolecules that would explain a primordial ribosome with both biocatalytic and genetic memory storage functions.

Original languageEnglish (US)
Title of host publicationEvolution of the Protein Synthesis Machinery and Its Regulation
PublisherSpringer International Publishing
Pages9-30
Number of pages22
ISBN (Electronic)9783319394688
ISBN (Print)9783319394671
DOIs
StatePublished - Jan 1 2016

Fingerprint

Transfer RNA
ribosomes
Ribosomes
translation (genetics)
Genetic Code
genetic code
Genes
History
Genome
aminoacyl tRNA ligases
history
genome
Biological Phenomena
Amino Acyl-tRNA Synthetases
Biochemistry
Proteins
Ribosomal Proteins
ribosomal proteins
Enzymes
Ligases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Caetano-Anollés, D., & Caetano-Anollés, G. (2016). The phylogenomic roots of translation. In Evolution of the Protein Synthesis Machinery and Its Regulation (pp. 9-30). Springer International Publishing. https://doi.org/10.1007/978-3-319-39468-8_2

The phylogenomic roots of translation. / Caetano-Anollés, Derek; Caetano-Anollés, Gustavo.

Evolution of the Protein Synthesis Machinery and Its Regulation. Springer International Publishing, 2016. p. 9-30.

Research output: Chapter in Book/Report/Conference proceedingChapter

Caetano-Anollés, D & Caetano-Anollés, G 2016, The phylogenomic roots of translation. in Evolution of the Protein Synthesis Machinery and Its Regulation. Springer International Publishing, pp. 9-30. https://doi.org/10.1007/978-3-319-39468-8_2
Caetano-Anollés D, Caetano-Anollés G. The phylogenomic roots of translation. In Evolution of the Protein Synthesis Machinery and Its Regulation. Springer International Publishing. 2016. p. 9-30 https://doi.org/10.1007/978-3-319-39468-8_2
Caetano-Anollés, Derek ; Caetano-Anollés, Gustavo. / The phylogenomic roots of translation. Evolution of the Protein Synthesis Machinery and Its Regulation. Springer International Publishing, 2016. pp. 9-30
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