TY - JOUR
T1 - The parts are greater than the whole
T2 - the role of semi-infectious particles in influenza A virus biology
AU - Diefenbacher, Meghan
AU - Sun, Jiayi
AU - Brooke, Christopher B.
N1 - Publisher Copyright:
© 2018
PY - 2018/12
Y1 - 2018/12
N2 - The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. Despite the remarkable selectivity and efficiency of this process, it is clear that the vast majority of IAV virions are unable to express the full set of essential viral gene products and are thus incapable of productive replication in the absence of complementation. Here, we attempt to reconcile the widespread production of these semi-infectious particles (SIPs) with the high efficiency and selectivity of IAV genome packaging. We also cover what is known and what remains unknown about the consequences of SIP production for the replication and evolution of viral populations.
AB - The influenza A virus (IAV) genome is incorporated into newly produced virions through a tightly orchestrated process that is one of the best studied examples of genome packaging by a segmented virus. Despite the remarkable selectivity and efficiency of this process, it is clear that the vast majority of IAV virions are unable to express the full set of essential viral gene products and are thus incapable of productive replication in the absence of complementation. Here, we attempt to reconcile the widespread production of these semi-infectious particles (SIPs) with the high efficiency and selectivity of IAV genome packaging. We also cover what is known and what remains unknown about the consequences of SIP production for the replication and evolution of viral populations.
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U2 - 10.1016/j.coviro.2018.07.002
DO - 10.1016/j.coviro.2018.07.002
M3 - Review article
C2 - 30053722
AN - SCOPUS:85050315199
SN - 1879-6257
VL - 33
SP - 42
EP - 46
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -