The P450 Gene Superfamily: Recommended Nomenclature

Daniel W. Nebert, Milton Adesnik, Minor J. Coon, Ronald W. Estabrook, Frank J. Gonzalez, F. Peter Guengerich, Irwin C. Gunsalus, Eric F. Johnson, Byron Kemper, Wayne Levin, Ian R. Phillips, Ryo Sato, Michael R. Waterman

Research output: Contribution to journalArticlepeer-review


A nomenclature for the P450 gene superfamily is proposed based on evolution. Recommendations include Roman numerals for distinct gene families, capital letters for subfamilies, and Arabic numerals for individual genes. An updating of this list, which presently includes 65 entries, will be required every 1–2 years. Assignment of orthologous genes is presently uncertain in some cases—between widely diverged species and especially in the P450II family due to the large number of genes. As more is known, it might become necessary to change some gene assignments that are based on our present knowledge.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
Issue number1
StatePublished - Feb 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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