The nuclear and DNA-associated molecular chaperone network

Zlata Gvozdenov, Janhavi Kolhe, Brian C. Freeman

Research output: Contribution to journalArticlepeer-review


Maintenance of a healthy and functional proteome in all cellular compartments is critical to cell and organismal homeostasis. Yet, our understanding of the proteostasis process within the nucleus is limited. Here, we discuss the identified roles of the major molecular chaperones Hsp90, Hsp70, and Hsp60 with client proteins working in diverse DNA-associated pathways. The unique challenges facing proteins in the nucleus are considered as well as the conserved features of the molecular chaperone system in facilitating DNA-linked processes. As nuclear protein inclusions are a common feature of protein-aggregation diseases (e.g., neurodegeneration), a better understanding of nuclear proteostasis is warranted.

Original languageEnglish (US)
Article numbera034009
JournalCold Spring Harbor Perspectives in Biology
Issue number10
StatePublished - Oct 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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