TY - JOUR
T1 - The neural underpinnings of motor learning in people with neurodegenerative diseases
T2 - A scoping review
AU - Aslan, Daniel H.
AU - Hernandez, Manuel E.
AU - Frechette, Mikaela L.
AU - Gephart, Aaron T.
AU - Soloveychik, Isaac M.
AU - Sosnoff, Jacob J.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Chronic progressive neurodegenerative diseases (NDD) cause mobility and cognitive impairments that disrupt quality of life. The learning of new motor skills, motor learning, is a critical component of rehabilitation efforts to counteract these chronic progressive impairments. In people with NDD, there are impairments in motor learning which appear to scale with the severity of impairment. Compensatory cortical activity plays a role in counteracting motor learning impairments in NDD. Yet, the functional and structural brain alterations associated with motor learning have not been synthesized in people with NDD. The purpose of this scoping review is to explore the neural alterations of motor learning in NDD. Thirty-five peer-reviewed original articles met the inclusion criteria. Participant demographics, motor learning results, and brain imaging results were extracted. Distinct motor learning associated compensatory processes were identified across NDD populations. Evidence from this review suggests the success of motor learning in NDD populations depends on the neural alterations and their interaction with motor learning networks, as well as the progression of disease.
AB - Chronic progressive neurodegenerative diseases (NDD) cause mobility and cognitive impairments that disrupt quality of life. The learning of new motor skills, motor learning, is a critical component of rehabilitation efforts to counteract these chronic progressive impairments. In people with NDD, there are impairments in motor learning which appear to scale with the severity of impairment. Compensatory cortical activity plays a role in counteracting motor learning impairments in NDD. Yet, the functional and structural brain alterations associated with motor learning have not been synthesized in people with NDD. The purpose of this scoping review is to explore the neural alterations of motor learning in NDD. Thirty-five peer-reviewed original articles met the inclusion criteria. Participant demographics, motor learning results, and brain imaging results were extracted. Distinct motor learning associated compensatory processes were identified across NDD populations. Evidence from this review suggests the success of motor learning in NDD populations depends on the neural alterations and their interaction with motor learning networks, as well as the progression of disease.
KW - Brain imaging
KW - Motor learning
KW - Neurodegenerative disorders
UR - http://www.scopus.com/inward/record.url?scp=85117392386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85117392386&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2021.10.006
DO - 10.1016/j.neubiorev.2021.10.006
M3 - Review article
C2 - 34624367
AN - SCOPUS:85117392386
SN - 0149-7634
VL - 131
SP - 882
EP - 898
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -