The many roles of glutamate in metabolism

Research output: Contribution to journalReview article

Abstract

The amino acid glutamate is a major metabolic hub in many organisms and as such is involved in diverse processes in addition to its role in protein synthesis. Nitrogen assimilation, nucleotide, amino acid, and cofactor biosynthesis, as well as secondary natural product formation all utilize glutamate in some manner. Glutamate also plays a role in the catabolism of certain amines. Understanding glutamate’s role in these various processes can aid in genome mining for novel metabolic pathways or the engineering of pathways for bioremediation or chemical production of valuable compounds.

Original languageEnglish (US)
Pages (from-to)419-430
Number of pages12
JournalJournal of Industrial Microbiology and Biotechnology
Volume43
Issue number2-3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Metabolism
Amino acids
Glutamic Acid
Bioremediation
Biosynthesis
Nucleotides
Glutamates
Amino Acids
Amines
Environmental Biodegradation
Genes
Metabolic Networks and Pathways
Nitrogen
Biological Products
Proteins
Genome

Keywords

  • Lanthipeptides
  • Lantibiotics
  • Natural products
  • Non-ribosomal peptide synthetase
  • Thiopeptides

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

The many roles of glutamate in metabolism. / Walker, Mark C.; van der Donk, Wilfred Adrianus.

In: Journal of Industrial Microbiology and Biotechnology, Vol. 43, No. 2-3, 01.03.2016, p. 419-430.

Research output: Contribution to journalReview article

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