The Influence of Methylphenidate on Spontaneous Autonomic Activity and Behavior in Children Diagnosed as Hyperactive

Stephen W. Porges; Robert E. Bohrer; Gideon Keren; Michael N. Cheung; George J. Franks; Fritz Drasgow

doi:10.1111/j.1469-8986.1981.tb01541.x

The Influence of Methylphenidate on Spontaneous Autonomic Activity and Behavior in Children Diagnosed as Hyperactive

Stephen W. Porges
, Robert E. Bohrer
, Gideon Keren
, Michael N. Cheung
, George J. Franks
, Fritz Drasgow

Research output: Contribution to journal › Article › peer-review

Abstract

Methylphenidate influenced the spontaneous autonomic activity of children diagnosed as hyperactive. There was dose response related reduction in disruptive classroom behavior monitored by the teacher ratings and a parallel decrease in a component of heart period variability, V, derived via spectral analysis of heart period activity. A low dose of methylphenidate, which has been reported to enhance cognitive performance, selectively increased a measure of respiratory‐cardiac coupling, C_w, derived via cross‐spectral analysis of respiration and heart period activity. It is hypothesized that C_w may be a quantitative manifestation of brainstem integration and V may be a quantitative estimate of effective vagal tone on the heart.

Original language	English (US)
Pages (from-to)	42-48
Number of pages	7
Journal	Psychophysiology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/j.1469-8986.1981.tb01541.x
State	Published - Jan 1981

Keywords

Coherence
Cross‐spectral analysis
Heart period variability
Hyperactive children
Methylphenidate
Vagal tone

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Neuropsychology and Physiological Psychology
Physiology (medical)
Physiology

Online availability

10.1111/j.1469-8986.1981.tb01541.x

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Cite this

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abstract = "Methylphenidate influenced the spontaneous autonomic activity of children diagnosed as hyperactive. There was dose response related reduction in disruptive classroom behavior monitored by the teacher ratings and a parallel decrease in a component of heart period variability, V, derived via spectral analysis of heart period activity. A low dose of methylphenidate, which has been reported to enhance cognitive performance, selectively increased a measure of respiratory‐cardiac coupling, Cw, derived via cross‐spectral analysis of respiration and heart period activity. It is hypothesized that Cw may be a quantitative manifestation of brainstem integration and V may be a quantitative estimate of effective vagal tone on the heart.",

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AU - Franks, George J.

AU - Drasgow, Fritz

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The Influence of Methylphenidate on Spontaneous Autonomic Activity and Behavior in Children Diagnosed as Hyperactive

Abstract

Keywords

ASJC Scopus subject areas

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