TY - JOUR
T1 - The impact of dose of FSH (Folltropin) containing LH (Lutropin) on follicular development, estrus and ovulation responses in prepubertal gilts
AU - Breen, Shawn M.
AU - Knox, Robert V.
N1 - Funding Information:
The authors sincerely thank JBS United, the University of Illinois swine research farm personnel, J. Taibl, D. Canaday, and K. Spencer for their assistance in animal management and collection of research data. The authors would also like to thank Bioniche Animal Health , for Folltropin and Lutropin and for generous financial support of this project.
PY - 2012/6
Y1 - 2012/6
N2 - FSH is favored over chorionic gonadotropins for induction of estrus in various species, yet little data are available for its effects on follicle development and fertility for use in pigs. For Experiment 1, prepubertal gilts (n= 36) received saline, 100. mg FSH, or FSH with 0.5. mg LH. Treatments were divided into six injections given every 8. h on Days 0 and 1. Proportions of gilts developing medium follicles were increased for FSH and FSH-LH (P< 0.05) compared to saline, but follicles were not sustained and fewer hormone-treated gilts developed large follicles (P< 0.05). No gilts expressed estrus and few ovulated. Experiment 2 tested FSH preparations with greater LH content. Prepubertal gilts (n= 56) received saline, FSH-hCG (100. mg FSH with 200. IU hCG), FSH-LH5 (FSH with 5. mg LH), FSH-LH10 (FSH with 10. mg LH), or FSH-LH20 (FSH with 20. mg LH). FSH-LH was administered as previously described, while 100. IU of hCG was given at 0. h and 24. h. Hormone treated gilts showed increased (P< 0.05) medium and large follicle development, estrus (>70%), ovulation (100%), and ovulation rate (>30 CL) compared to saline. There was an increase (P< 0.05) in the proportion of hormone-treated gilts with follicular cysts at Day 5, but these did not persist to Day 22. These gilts also showed an increase in poorly formed CL (P< 0.05). FSH alone or with small amounts of LH can induce medium follicle growth but greater amounts of LH at the same time is needed to sustain medium follicles, stimulate development of large follicles and induce estrus and ovulation in prepubertal gilts.
AB - FSH is favored over chorionic gonadotropins for induction of estrus in various species, yet little data are available for its effects on follicle development and fertility for use in pigs. For Experiment 1, prepubertal gilts (n= 36) received saline, 100. mg FSH, or FSH with 0.5. mg LH. Treatments were divided into six injections given every 8. h on Days 0 and 1. Proportions of gilts developing medium follicles were increased for FSH and FSH-LH (P< 0.05) compared to saline, but follicles were not sustained and fewer hormone-treated gilts developed large follicles (P< 0.05). No gilts expressed estrus and few ovulated. Experiment 2 tested FSH preparations with greater LH content. Prepubertal gilts (n= 56) received saline, FSH-hCG (100. mg FSH with 200. IU hCG), FSH-LH5 (FSH with 5. mg LH), FSH-LH10 (FSH with 10. mg LH), or FSH-LH20 (FSH with 20. mg LH). FSH-LH was administered as previously described, while 100. IU of hCG was given at 0. h and 24. h. Hormone treated gilts showed increased (P< 0.05) medium and large follicle development, estrus (>70%), ovulation (100%), and ovulation rate (>30 CL) compared to saline. There was an increase (P< 0.05) in the proportion of hormone-treated gilts with follicular cysts at Day 5, but these did not persist to Day 22. These gilts also showed an increase in poorly formed CL (P< 0.05). FSH alone or with small amounts of LH can induce medium follicle growth but greater amounts of LH at the same time is needed to sustain medium follicles, stimulate development of large follicles and induce estrus and ovulation in prepubertal gilts.
KW - Estrus
KW - FSH
KW - Gilt
KW - LH
KW - Ovulation
KW - Puberty
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U2 - 10.1016/j.anireprosci.2012.05.013
DO - 10.1016/j.anireprosci.2012.05.013
M3 - Article
C2 - 22683028
AN - SCOPUS:84863219646
SN - 0378-4320
VL - 132
SP - 193
EP - 200
JO - Animal reproduction science
JF - Animal reproduction science
IS - 3-4
ER -