The impact of aberrations on object reconstruction with interferometric synthetic aperture microscopy

Steven G. Adie, Benedikt W. Graf, Adeel Ahmad, Budiman Darbarsyah, Stephen A. Boppart, P. Scott Carney

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Interferometric synthetic aperture microscopy (ISAM) reconstructs the scattering potential of a sample with spatially invariant resolution, based on the incident beam profile, the beam scan pattern, the physical model of light sample interaction, and subsequent light collection by the system. In practice, aberrations may influence the beam profile, particularly at higher NA, when ISAM is expected to provide maximum benefit over optical coherence microscopy. Thus it is of interest to determine the effects of aberrations on ISAM reconstructions. In this paper we present the forward model incorporating the effects of aberrations, which forms the basis for aberration correction in ISAM. Simulations and experimental results show that when operating far from focus, modest amounts of spherical aberration can introduce artifacts to the point-spread function, even at relatively low NA ~ 0.1-0.2. Further work will investigate computational methods to correct the effects of aberrations, i.e. to perform virtual adaptive optics.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
DOIs
StatePublished - Apr 12 2011
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Keywords

  • aberration correction
  • holography
  • Interferometric synthetic aperture microscopy
  • optical coherence microscopy
  • optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Adie, S. G., Graf, B. W., Ahmad, A., Darbarsyah, B., Boppart, S. A., & Carney, P. S. (2011). The impact of aberrations on object reconstruction with interferometric synthetic aperture microscopy. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV [78891O] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7889). https://doi.org/10.1117/12.875592