TY - JOUR
T1 - The HOX-5 and surfeit gene clusters are linked in the proximal portion of mouse chromosome 2
AU - Stubbs, Lisa
AU - Huxley, Clare
AU - Hogan, Brigid
AU - Evans, Timothy
AU - Fried, Mike
AU - Duboule, Denis
AU - Lehrach, Hans
N1 - Funding Information:
We thank Maja Bucan for advice during the initial stages of this project, Maja Bucan and Jiri Forejt for their critical comments on the manuscript, and Michele Price for help in preparing the manuscript. This work was supported in part by a grant from the U.S. National Institutes of Health (ROl EY08000-01) awarded to B.H.
PY - 1990/4
Y1 - 1990/4
N2 - Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2.
AB - Using an interspecies backcross, we have mapped the HOX-5 and surfeit (surf) gene clusters within the proximal portion of mouse chromosome 2. While the HOX-5 cluster of homeobox-containing genes has been localized to chromosome 2, bands C3-E1, by in situ hybridization, its more precise position relative to the genes and cloned markers of chromosome 2 was not known. Surfeit, a tight cluster of at least six highly conserved "housekeeping" genes, has not been previously mapped in mouse, but has been localized to human chromosome 9q, a region of the human genome with strong homology to proximal mouse chromosome 2. The data presented here place HOX-5 in the vicinity of the closely linked set of developmental mutations rachiterata, lethargic, and fidget and place surf close to the proto-oncogene Abl, near the centromere of chromosome 2.
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U2 - 10.1016/0888-7543(90)90499-K
DO - 10.1016/0888-7543(90)90499-K
M3 - Article
C2 - 1971250
AN - SCOPUS:0025328031
SN - 0888-7543
VL - 6
SP - 645
EP - 650
JO - Genomics
JF - Genomics
IS - 4
ER -