The golden age: Gold nanoparticles for biomedicine

Erik C. Dreaden, Alaaldin M. Alkilany, Xiaohua Huang, Catherine J. Murphy, Mostafa A. El-Sayed

Research output: Contribution to journalReview article

Abstract

Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).

Original languageEnglish (US)
Pages (from-to)2740-2779
Number of pages40
JournalChemical Society Reviews
Volume41
Issue number7
DOIs
StatePublished - Apr 7 2012

Fingerprint

Gold
Nanoparticles
Biological systems
Nanotechnology
Health
Nanoscience
Molecules
Biocompatibility
Electronic properties
Optoelectronic devices
Medicine
Physical properties
Color

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El-Sayed, M. A. (2012). The golden age: Gold nanoparticles for biomedicine. Chemical Society Reviews, 41(7), 2740-2779. https://doi.org/10.1039/c1cs15237h

The golden age : Gold nanoparticles for biomedicine. / Dreaden, Erik C.; Alkilany, Alaaldin M.; Huang, Xiaohua; Murphy, Catherine J.; El-Sayed, Mostafa A.

In: Chemical Society Reviews, Vol. 41, No. 7, 07.04.2012, p. 2740-2779.

Research output: Contribution to journalReview article

Dreaden, EC, Alkilany, AM, Huang, X, Murphy, CJ & El-Sayed, MA 2012, 'The golden age: Gold nanoparticles for biomedicine', Chemical Society Reviews, vol. 41, no. 7, pp. 2740-2779. https://doi.org/10.1039/c1cs15237h
Dreaden, Erik C. ; Alkilany, Alaaldin M. ; Huang, Xiaohua ; Murphy, Catherine J. ; El-Sayed, Mostafa A. / The golden age : Gold nanoparticles for biomedicine. In: Chemical Society Reviews. 2012 ; Vol. 41, No. 7. pp. 2740-2779.
@article{789a709bda064ffab1f31d8b451787ac,
title = "The golden age: Gold nanoparticles for biomedicine",
abstract = "Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).",
author = "Dreaden, {Erik C.} and Alkilany, {Alaaldin M.} and Xiaohua Huang and Murphy, {Catherine J.} and El-Sayed, {Mostafa A.}",
year = "2012",
month = "4",
day = "7",
doi = "10.1039/c1cs15237h",
language = "English (US)",
volume = "41",
pages = "2740--2779",
journal = "Chemical Society Reviews",
issn = "0306-0012",
publisher = "Royal Society of Chemistry",
number = "7",

}

TY - JOUR

T1 - The golden age

T2 - Gold nanoparticles for biomedicine

AU - Dreaden, Erik C.

AU - Alkilany, Alaaldin M.

AU - Huang, Xiaohua

AU - Murphy, Catherine J.

AU - El-Sayed, Mostafa A.

PY - 2012/4/7

Y1 - 2012/4/7

N2 - Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).

AB - Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracted tremendous attention due to their historical applications in art and ancient medicine and current applications in enhanced optoelectronics and photovoltaics. In spite of their modest alchemical beginnings, gold nanoparticles exhibit physical properties that are truly different from both small molecules and bulk materials, as well as from other nanoscale particles. Their unique combination of properties is just beginning to be fully realized in range of medical diagnostic and therapeutic applications. This critical review will provide insights into the design, synthesis, functionalization, and applications of these artificial molecules in biomedicine and discuss their tailored interactions with biological systems to achieve improved patient health. Further, we provide a survey of the rapidly expanding body of literature on this topic and argue that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us. Moving forward, the most challenging nanoscience ahead of us will be to find new chemical and physical methods of functionalizing gold nanoparticles with compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term term effects on human health and reproduction (472 references).

UR - http://www.scopus.com/inward/record.url?scp=84858676731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858676731&partnerID=8YFLogxK

U2 - 10.1039/c1cs15237h

DO - 10.1039/c1cs15237h

M3 - Review article

C2 - 22109657

AN - SCOPUS:84858676731

VL - 41

SP - 2740

EP - 2779

JO - Chemical Society Reviews

JF - Chemical Society Reviews

SN - 0306-0012

IS - 7

ER -