@article{8314e99b4b604060aec8a7404e40cf17,
title = "The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits",
abstract = "Several attributes intuitively considered to be typical mammalian features, such as complex behavior, live birth and malignant disease such as cancer, also appeared several times independently in lower vertebrates. The genetic mechanisms underlying the evolution of these elaborate traits are poorly understood. The platyfish, X. maculatus, offers a unique model to better understand the molecular biology of such traits. We report here the sequencing of the platyfish genome. Integrating genome assembly with extensive genetic maps identified an unexpected evolutionary stability of chromosomes in fish, in contrast to in mammals. Genes associated with viviparity show signatures of positive selection, identifying new putative functional domains and rare cases of parallel evolution. We also find that genes implicated in cognition show an unexpectedly high rate of duplicate gene retention after the teleost genome duplication event, suggesting a hypothesis for the evolution of the behavioral complexity in fish, which exceeds that found in amphibians and reptiles.",
author = "Manfred Schartl and Walter, {Ronald B.} and Yingjia Shen and Tzintzuni Garcia and Julian Catchen and Angel Amores and Ingo Braasch and Domitille Chalopin and Volff, {Jean Nicolas} and Lesch, {Klaus Peter} and Angelo Bisazza and Pat Minx and Ladeana Hillier and Wilson, {Richard K.} and Susan Fuerstenberg and Jeffrey Boore and Steve Searle and Postlethwait, {John H.} and Warren, {Wesley C.}",
note = "Funding Information: The authors would like to thank the staff of the Xiphophorus Genetic Stock Center (XGSC) and the Biocenter Fish Facility for maintaining the pedigreed fish lines used in this study. We gratefully acknowledge the sequencing efforts of C. Fronick, K. Delehaunty and the production sequencing group at the Genome Institute. This work was supported by US National Institutes of Health, National Center for Research Resources (NCRR) and Office of Research Infrastructure Programs (ORIP), Division of Comparative Medicine grants R24 RR024790 and R24 OD011120 (R.B.W.), including an American Recovery and Reinvestment Act supplement to this award, and R24OD011199 (R.B.W.), R24 RR032658 and R24 OD011198 (W.C.W.), R01 RR020833 and R01 OD011116 (J.H.P.), by the Deutsche Forschungsgemeinschaft, TRR 58/A5 (K.P.L.) and TRR 17 (M.S.) VolkswagenStiftung, grant I/84 815 (I.B.) and by the Agence Nationale de Recherche (J.-N.V.).",
year = "2013",
month = may,
doi = "10.1038/ng.2604",
language = "English (US)",
volume = "45",
pages = "567--572",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "5",
}